Alteration of Proteasome System in Aging and Aging-Associated Disorders

The proteasome system is crucial in protein metabolism involving in physiological and pathological developments, especially in aging and agingrelated disorders. Here we discussed the relationship of proteasome with other metabolic systems such as lysosome and ribosome as well as the alteration of proteasome system under oxidative stress, aging and other pathological conditions. Due to its essential roles, the proteasome system provides an active target for therapeutic development in many different pathological conditions. Ding Q, Zhu H (2015) Alteration of Proteasome System in Aging and Aging-Associated Disorders. Int J Drug Dev & Res 7: 027-030 Volume 7(4): 027-030 (2015)-028 Int J Drug Dev & Res ISSN: 0975-9344 disorders. The senile plaques and tangles in AD, Lewy bodies and Lewy threads in PD and Dementia with Lewy Body, and the mutant htt aggregates in HD are well documented examples of protein aggregation. Inhibition of proteasome and lysosome systems could induce α-synuclein aggregation directly [21], and protein aggregation could induce proteasome dysfunction as well [22]. Nevertheless, proteasomal subunits could also form aggregates [23]. Although the proteasome impairment and protein aggregation mostly occur in pathological conditions [23,24] protein aggregation could form in healthy cells without inhibition of proteasome and may have detoxic function [25]. In summary, dysfunction of proteasome is sufficient to induce protein aggregation even cell death, but may not be necessary; protein aggregation could induce proteasome inhibition in selected conditions. Generally proteasome is responsible to remove protein aggregation but their interaction is not a simple two-element game, other factors including oxidative stress and ubiquitiation might also take part in the interaction.